Top 10 publications of UPD College of Science in 2023

Top 10 publications of UPD College of Science in 2023

Published: January 25, 2024

By: Harvey L. Sapigao

In 2023, about 1 in 20 studies produced by the Philippines came from the UP Diliman College of Science (UPD-CS). With a total of 368 studies across all scientific disciplines, UPD-CS studies accounted for more than half of the total publications produced by UP Diliman. This number comes as no surprise since the College is home to 211 Ph.D faculty members. But beyond the numbers, UPD-CS has published groundbreaking research in many prestigious research journals.

 

Here are the Top 10 studies published by UPD-CS scientists in journals with high Impact Factors (IF)*:

 

1. Shedding Light on Mysterious Superconductors (IF: 41.2)

 

Superconductors allow electricity to pass through with no resistance. Previously, it was believed that when excessive electrons are removed from a mysterious type of superconductor called  cuprate superconductor, known as “overdoping,” the material would behave in accordance with the Bardeen–Cooper–Schrieffer (BCS) theory. However, Dr. Miguel Sulangi of the National Institute of Physics and collaborators from the Netherlands, Japan, China, and the USA showed that this is not the case, challenging the long-held belief that BCS theory governs overdoped cuprate superconductors. Cuprate superconductors were discovered in 1986 but physicists have yet to uncover all its secrets.

 

Read the press release here: https://science.upd.edu.ph/upd-cs-nip-physicist-co-authors-groundbreaking-research-on-mysterious-superconductors/ 

 

Title: Puddle formation and persistent gaps across the non-mean-field breakdown of superconductivity in overdoped (Pb,Bi)2Sr2CuO6+δ

Journal: Nature Materials

DOI: https://doi.org/10.1038/s41563-023-01497-1

 

2. Applying Einstein’s Concepts of Relativity to Exotic Particles (IF: 16.6)

 

Einstein’s Theory of Relativity claims that two events can only influence one another if they are inside each other’s spacetime area called the light cone. Borrowing this concept, Dr. Gennevieve Macam of the National Institute of Physics worked with an international team of researchers to explain how two exotic particles called Weyl fermions interact. Their study is the first to describe Weyl fermions in terms of spacetime concepts, demonstrating how two physics disciplines – condensed matter physics and high-energy physics – are fundamentally connected.

 

Read the press release here: https://science.upd.edu.ph/beyond-einstein-pinay-physicist-investigates-exotic-subtonic-particles/ 

 

Title: Causal Structure Of Interacting Weyl Fermions In Condensed Matter Systems

Journal: Nature Communications

DOI: https://doi.org/10.1038/s41467-023-37931-w

 

3. History of Single-celled Predators (IF: 15.9)

 

Single-celled organisms, like the protists Acanthamoeba and Dictyostelium, use metals to kill bacterial prey. Exactly how these organisms evolved is the focus of the study by Dr. Windell Rivera and collaborators from China. They provided a timeline for the evolution of metal-poisoning protists, from the moment protists were created to the time they adapted to the environment and acquired the ability to use metals in killing their prey.

 

Title: A Brief History Of Metal Recruitment In Protozoan Predation

Journal: Trends in Microbiology

DOI: https://doi.org/10.1016/j.tim.2023.11.008 

 

4. Identifying First Bacteria Colonizers on Plastics (IF: 13.6)

 

Many types of bacteria live on plastics left in the environment. But for diverse colonies to thrive, a group of bacteria, called primo-colonizers, must first prime the plastics to make them habitable for other types of bacteria. Justine Marey Bitalac, Norchel Corcia Gomez, and Dr. Deo Florence Onda of the Marine Science Institute, together with Dr. Nacita Lantican of UP Los Baños, identified these primo-colonizers and described how they change the structure of plastics. Their study helps elucidate how plastics degrade in the environment and opens possibilities on how to solve the growing plastic pollution problem.

 

Title: Attachment Of Potential Cultivable Primo-Colonizing Bacteria And Its Implications On The Fate Of Low-Density Polyethylene (LDPE) Plastics In The Marine Environment

Journal: Journal of Hazardous Materials

DOI: https://doi.org/10.1016/j.jhazmat.2023.131124

 

5. Simulating the Spread of Monkeypox (IF: 12.7)

 

Together with South Korean scientists, Drs. Victoria May Mendoza and Renier Mendoza of the Institute of Mathematics investigated the importance of self-reporting and contact tracing in controlling epidemics. They simulated how self-reporting and contact tracing affect the spread of monkeypox in non-endemic regions. They found out that an unreported primary case with delayed contact tracing can potentially increase the average number of infections by up to 40% compared to when the primary case is known and contact tracing is immediate.

 

Title: Estimation Of Monkeypox Spread In A Non-Endemic Country Considering Contact Tracing And Self-Reporting: A Stochastic Modeling Study

Journal: Journal of Medical Virology

DOI: https://doi.org/10.1002/jmv.28232

 

6. Classifying Seaweeds in the Philippines (IF: 11.5)

 

Seaweeds such as the milyon-milyon, tambalang, and kab-kab are abundant in the Philippines, making the country one of the leading seaweed farming industries in the world. Despite this, Philippine seaweeds are undocumented. Bea Crisostomo, Zae-Zae Aguinaldo, Lourie Ann Hinaloc, and Dr. Michael Roleda of the Marine Science Institute established the taxonomy and distribution of different seaweeds in the Philippines using knowledge from local farmers. Their study provides a database of seaweeds that can be used for conservation efforts.

 

Title: The Diversity Of Eucheumatoid Seaweed Cultivars In The Philippines

Journal: Reviews in Fisheries Science & Aquaculture

DOI: https://doi.org/10.1080/23308249.2022.2060038

 

7. Tropical Cyclones and their Threat to Food Security, Health, and Biodiversity (IF: 11.1)

 

Damages brought by tropical cyclones produce a cascading effect on food security, health, and biodiversity. In a perspective paper by Dr. Rene Abesamis of the Marine Science Institute and collaborators from Chile, Japan, Switzerland, and Norway, they explained that tropical cyclones can damage roads, agricultural infrastructure, and grazing lands, which affects food production. The destruction of tropical ecosystems also affects food security, which in turn produces health problems such as micronutrient deficiency. The authors urge researchers to develop tools that can aid in policy-making and governments to coordinate closely in a collaborative effort to curb the effects of tropical cyclones.

 

Title: Impacts Of Tropical Cyclones On Food Security, Health And Biodiversity

Journal: Bulletin of the World Health Organization

DOI: http://dx.doi.org/10.2471/BLT.22.288838

 

8. Tracking Human Settlers in the Holocene Period Using Genetics (IF: 11.1)

 

By analyzing almost two decades’ worth of genomic data, Jae Joseph Russell Rodriguez of the Natural Sciences Research Institute and international researchers traced how humans migrated around the world and how they facilitated the spread of language and agriculture about ten thousand years ago. In Southeast Asia, their study suggests that human settlers in the region, referred to as Austronesians, first migrated from China to Taiwan, then moved southward to the Philippines, Indonesia, and Papua New Guinea. Using sophisticated boating technology, Austronesians were then able to reach islands as far as Madagascar and Hawaii.

 

Title: Genomic Perspectives On Human Dispersals During The Holocene

Journal: Proceedings of the National Academy of Sciences

DOI: https://doi.org/10.1073/pnas.2209475119

 

9. Water-purifying Nanoparticles (IF: 9.9)

 

As water pollution becomes an ever-more pressing issue, we are in dire need of technologies that can purify water. Dr. Michelle Regulacio of the Institute of Chemistry collaborated with scientists from China to create a nanocomposite that can get rid of water contaminants with the help of light. The nanocomposites, made up of zinc oxide and carbon, can easily cling to organic dyes and bacteria and, using energy from light, decompose or kill them. The nanocomposites are cheap and simple to manufacture, offering a cost-effective wastewater treatment system.

 

Title: Hydrophilic ZnO/C Nanocomposites With Superior Adsorption, Photocatalytic, And Photo-Enhanced Antibacterial Properties For Synergistic Water Purification

Journal: Journal of Colloid and Interface Science

DOI: https://doi.org/10.1016/j.jcis.2023.06.019

 

10. Marine Pollution and Its Effects on Southeast Asian Biodiversity (IF: 9.8)

 

Southeast Asia is one of the most biodiverse regions in the world while also contributing significantly to marine pollution. Yet the region is underrepresented in studies that focus on the effects of marine pollution on biodiversity. In their review paper, Dr. Lemnuel Aragones of the Institute of Environmental Science and Meteorology and partners in Southeast Asia investigated why this is the case. They found out that these sorts of studies are complicated by language barriers, sociocultural limitations, and difficulties in examining species.

 

Title: Interactions Between Marine Megafauna And Plastic Pollution In Southeast Asia

Journal: Science of The Total Environment

DOI: https://doi.org/10.1016/j.scitotenv.2023.162502

 

In addition, here are the top studies published by UPD-CS-affiliated authors in high IF journals:

 

Using Algorithms to Model Social Behaviors (IF: 11.25)

 

Algorithms such as machine learning (ML) are better at classifying social responses than conventional statistical tools. That’s what Dr. Armando Apan of the Institute of Environmental Science and Meteorology (IESM) and collaborators from Nepal concluded in their research that looked upon the perspective of Nepalese people on energy consumption. ML models of public perceptions can aid in policy-making, planning, and implementation.

 

Title: Application Of Machine Learning To Assess People’s Perception Of Household Energy In The Developing World: A Case Of Nepal

Journal: Energy and AI

DOI: https://doi.org/10.1016/j.egyai.2023.100303

 

Examining Ecosystem Services in the Himalayas (IF: 11.1)

 

Services from nature like water supply, crop production, and habitat quality are called ecosystem services. Ecosystem services have unique relationships with one another. For example, when farmers convert forests into farms to increase crop production, the habitat quality will decrease. These unique relationships are the research focus of Dr. Armando Apan of the IESM and his partners in Nepal. They looked into how each ecosystem service changes with respect to one another and examined how this affects the ways of living in the Himalayas.

 

Title: Understanding Production Possibility Frontiers And Utility Values Of Ecosystem Services In The Himalayas: An Analysis Of The Supply-Demand Divide

Journal: Journal of Cleaner Production

DOI: https://doi.org/10.1016/j.jclepro.2023.138725

 

Why Renewable Energy Sources are Failing in Nepal (IF: 9)

 

The threat of climate change urges countries to transition to renewable energy sources, but developing countries such as Nepal struggle to do so. Dr. Armando Apan of the IESM and collaborators from Nepal examined the reasons and learned that solar and wind technologies shut down because of poor planning and fund discontinuation. Dr. Apan and collaborators emphasized the need to tackle the issue using “bottom-up” approaches that consider local contexts rather than “top-down” approaches that only look at the issue as mere technological transfers.

 

Title: Rationalizing donations and subsidies: Energy ecosystem development for sustainable renewable energy transition in Nepal

Journal: Energy Policy

DOI: https://doi.org/10.1016/j.enpol.2023.113570

 

* The metric Impact Factor (IF) measures the average number of times research papers are cited. For example, a journal with an IF of 9 means that, on average, research papers published in that journal are cited 9 times.

UP Chemists Modify Anticancer Compound to Improve Safety and Efficacy

UP Chemists Modify Anticancer Compound to Improve Safety and Efficacy

Published: January 23, 2024

By: Harvey L. Sapigao

Chemical structure of deguelin. (Photo credit: Francisco, J. A., & Paderes, M. C. Inhibitory effects of B-, C-, and E-ring-truncated deguelin derivatives against A549, HCT116, and MCF-7 Cancer Cells. ACS Omega, 8(45): p. 43109–43117)

Scientists from the University of the Philippines – Diliman College of Science (UPD-CS) have transformed the anticancer compound deguelin into a novel class of compounds that show promise as safer and more effective treatments for colon, lung, and breast cancer.

 

Originally used as a pesticide and fish poison, concerns arose regarding the safety of administering deguelin to humans once it was identified as a cancer treatment. Science Research Specialist John Alfon Francisco and Dr. Monissa Paderes of the UPD-CS Institute of Chemistry (UPD-CS IC) addressed these concerns by altering the structure of deguelin.

 

Their altered versions exhibited better qualities than the original compound. Preliminary tests done on human cancer cell cultures revealed reduced adverse effects, prompting Dr. Paderes and collaborators to conduct further research into the safety of these compounds.

 

Some versions are also more effective against specific types of cancer. “We were amused to find that some compounds have improved anticancer properties than its parent compound, deguelin, with some even surpassing the effectiveness of the commercially available anticancer drug doxorubicin,” Francisco said. For instance, a version named 6a outperformed doxorubicin in treating colon cancer, while versions 3a and 8e excelled in treating lung and breast cancer, respectively.

 

Their modified versions offer a simpler and more cost-effective production than those developed in previous studies. “The simplicity of the structures, as well as the straightforward synthesis of these compounds, add to the novelty of this study,” Dr. Paderes emphasized.

 

The researchers created the altered versions by shortening a part of deguelin known as the BCE ring, making the new versions more akin to the deoxybenzoin compound, recognized for its antibacterial and antioxidant properties.

 

Despite its huge commercial potential, their research is still in its early stages. The next phase involves testing the modified anticancer compounds on animal models. If the compounds are proven effective on animals, it will move on to clinical trials, where it will be tested on humans with colon, lung, or breast cancer. If proven successful, the Food and Drug Administration (FDA) will review and approve the rollout of the compounds as cancer treatments.

 

“The goal would be to advance these compounds toward clinical trials and potential development as novel anticancer therapeutics,” Dr. Paderes concluded.

 

For interview requests and other concerns, please contact media@science.upd.edu.ph



References:

Francisco, J. A., & Paderes, M. C. (2023). Inhibitory effects of B-, C-, and E-ring-truncated deguelin derivatives against A549, HCT116, and MCF-7 Cancer Cells. ACS Omega, 8(45), 43109–43117. https://doi.org/10.1021/acsomega.3c06619

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“No patent, no right”: UP lawyer highlights scientists’
need to protect inventions

“No patent, no right”: UP lawyer highlights scientists’ need to protect inventions

Published: January 10, 2024

By: Harvey L. Sapigao

In the ’90s, Dr. Neila Cortes-Maramba of UP Manila led a team of scientists investigating ten medicinal plants in the Philippines. Two of these plants exhibited promising results—one for cough and the other for urinary tract infections. The team patented Vitex negundo (Lagundi) and Blumea balsamifera (Sambong) in syrup and tablet forms, granting them exclusive rights to these medicines. 

 

Today, Lagundi and Sambong are essential remedies for coughs and UTIs, proving lucrative for the pharmaceutical industry. Had they not applied for a patent, UP Manila and its partners would not have earned more than 50 million pesos in remittances through royalties and licensing fees, nor would they have been able to claim the invention as their own and would leave it vulnerable to idea theft.

 

If inventions and creations are not patented, “it belongs now to the public domain where anyone can reproduce or manufacture it,” Atty. Josephine R. Santiago of the UP Diliman College of Law said at the 7th session of the iStories webinar, hosted by the University of the Philippines – Diliman College of Science. Atty. Santiago is an award-winning intellectual property (IP) expert who served as the Director General of the Intellectual Property Office of the Philippines (IPOPHL).

Failing to patent inventions exposes them to the public domain, allowing anyone to reproduce or manufacture them. (Photo credit: Eunice Jean Patron)

A patent, as a form of IP, provides the inventor exclusive rights to their creations. “The right of a patentee is only to prevent third persons from manufacturing, offering for sale, using, selling, or importing the invention,” Atty. Santiago explained. “It is not to make the invention, but to prevent others.” She added that, when multiple inventors unknowingly created the same invention, the first to file the patent secures the rights to it.

 

UP Diliman has successfully patented various inventions, such as CoaTiN, a coating technology that uses titanium nitride to extend the lifespan of metallic tools, developed by Dr. Henry Ramos of the National Institute of Physics (NIP), and an amebiasis detection kit that quickly identifies the disease using saliva, invented by Dr. Windell Rivera, Dr. Angeline Odelia Concepcion, and Dr. Alexander Edward Dy of the Institute of Biology (IB).

 

Patents not only benefit inventors but also stimulate innovation and improve existing products. Applying for patents requires detailed explanations of how the invention works. This information becomes publicly available upon patent approval, allowing other inventors to draw inspiration from or enhance the patented work.

 

Atty. Santiago also touched upon the other three types of IP: trademarks, which protect identifying symbols and expressions; copyright which grants rights from the moment of creation; and trade secrets, which safeguards valuable confidential information.

 

She will also discuss harnessing IP for innovation in another iStories session.

 

iStories is a series of monthly innovation-themed talks, storytelling, and activities featuring local and international scientists. The initiative aims to ignite the creativity and inventiveness of young scientists not just from UPD-CS but also from other institutes inside and outside of UP.

 

For inquiries about iStories, please message adride_staff@science.upd.edu.ph 

 

For interview requests and other media concerns, please contact media@science.upd.edu.ph

Congratulations! Dr. Gino Angelo Velasco

A huge congratulations to Dr. Gino Angelo Velasco, Associate Professor at the Institute of Mathematics, on receiving the prestigious 2023 UP CASAF J. Antonio Aguenza Professorial Chair (Public Service)! 🌟

 

Your dedication to academia and public service is truly commendable. Congratulations on this well-deserved recognition! 🏆

More intense typhoons to come this century, UP study warns

More intense typhoons to come this century, UP study warns

Published: December 15, 2023

By: Harvey L. Sapigao

Warming of sea surface in Asia-Pacific. Redder areas indicate a higher increase in temperature. (Photo credit: Delfino, R.J. et al. Response of damaging Philippines tropical cyclones to a warming climate using the pseudo global warming approach. Clim Dyn 61 (2023): p. 3506.)

The Philippines should brace for potentially stronger and more destructive typhoons due to climate change, warns new research coming out of the University of the Philippines – Diliman College of Science’s  Institute of Environmental Science and Meteorology (UPD-CS IESM).


Dr. Rafaela Jane Delfino and Dr. Gerry Bagtasa, together with colleagues from the UK, found that future Philippine typhoons may have a higher cyclone damage potential (CDP) than today’s typhoons. 


CDP is a metric that takes into account several factors, including the size of the cyclone and the speed of its winds. The scientists gathered data from recent typhoons and projected these onto likely future climate scenarios to figure out future CDPs. The greater the CDP, the greater potential damage costs, particularly from winds.


Specifically, the researchers looked at three of the most deadly super typhoons in recent history: Haiyan (which happened in 2013 and was locally named Yolanda); Bopha (2012, Pablo); and Mangkhut (2018, Ompong). They then hypothesized the potential damage from these typhoons if they happened in a future where the climate is forecast to be warmer and more humid, based on multiple climate projections for the years 2070 to 2099. 


Moreover, by employing various projections and considering several factors such as atmospheric temperature, sea surface temperature, pressure, and relative humidity, the researchers were able to conclusively link climate change to the intensification of the three Philippine typhoons mentioned in the study. They also found that future typhoons may be expected to be stronger and more damaging. Like spinning tops, the potentially faster winds and slower movement of these future typhoons could lead to them lingering longer over land and therefore causing more damage.


For example, under one forecast model, the CDP from a future cyclone similar to Super Typhoon Yolanda was seen to be as much as 37% greater than the damage experienced in 2013. In another simulation, Super Typhoon Ompong, which had a simulated maximum wind speed of 205 kph under present climate conditions, could potentially hit 270 kph under future climate conditions. The projections also showed an increase of as much as 50 kph in the maximum wind speeds of future typhoons like Yolanda and Pablo.


“Based on our simulations, it is found that the most damaging tropical cyclones like Haiyan, Bopha, and Mangkhut will have higher wind-related damage potential in the future,” the researchers concluded in their paper. 


“Tropical cyclones of such intensity and damage potential in the future will have serious implications with the increasing exposure and vulnerability in the Philippines,” they added, calling for further research using other models and typhoon data sets.


For interview requests and other concerns, please contact media@science.upd.edu.ph


References:

Delfino, R.J., Vidale, P.L., Bagtasa, G. et al. Response of damaging Philippines tropical cyclones to a warming climate using the pseudo global warming approach. Clim Dyn 61, 3499–3523 (2023). https://doi.org/10.1007/s00382-023-06742-6

UP STS scientists assess the effectiveness of the Philippines’ COVID-19 government policies

UP STS scientists assess the effectiveness of the Philippines’ COVID-19 government policies

Published: December 13, 2023

By: Harvey L. Sapigao

The COVID-19 pandemic spurred governments worldwide to respond with containment policies, with the Philippines having one of the longest and most stringent COVID-19 policies in the world. How effective were these policies in containing the pandemic and providing social and economic support to citizens? This is the question UP Diliman College of Science’s Science, Technology and Society (UPD-CS STS) researchers ventured to answer.

A novel, multidisciplinary approach


STS scientists and faculty members Prof. Benjamin Vallejo Jr, Dr. Rodrigo Angelo Ong and Asst. Prof. Ranjit Singh Rye found a new interdisciplinary approach to the problem: “We just adopted statistical methods commonly used in marine behavioral ecology. After all, government policy response is a set of behaviors that can be standardized and compared with each other. The most significant behavioral responses can be statistically modeled,” Vallejo said.


“Furthermore, a multidisciplinary perspective allows for a better contextualization of how effective the policies are,” he added.


Using standardized policy response measures collated by the Oxford COVID-19 Government Response Tracker project (OxCGRT), they assessed the effectiveness of the Philippine response from 2020 to 2022. The OxCGRT includes daily policy response and implementation data from 180 World Health Organization (WHO)-member states,  from 1 Jan 2020 to 31 Dec 2022.


The STS scientists were able to determine that stringent pandemic policies—including lockdowns, quarantines, stay-at-home ordinances, and travel restrictions—were effective in containing the pandemic within the first 60 days. These are all dependent on law enforcement and a securitized approach. 


Effectivity of lockdowns and vaccinations


Complete lockdowns negatively affected the economy, so there was a gradual and phased relaxing of policies beginning in May 2020. It was during the relaxing of lockdowns with limited mobility starting with essential personnel that the shortcomings of the government’s response became apparent. With lockdowns being phased out, contact tracing and testing became more necessary to immediately contain clusters of infections. The government was least effective in these efforts.

The policy analysis also revealed that the government’s vaccination rollout and prioritization, although with logistical difficulties at the start, was effective in reducing infections in the health workers sector and thus ensuring the delivery of health services The health workers received the vaccine in a shorter timeframe than the rest of the population beginning March 2021. Overall, it can be said that vaccination caused a more positive outcome in the pandemic. 


It was also found that the continuation of travel health checks—such as requiring proof of vaccination, COVID-19 rtPCR tests, and, later, antigen tests—had a low odds ratio to the rate of COVID-19 case increase. This simply means that these requirements lessened the risk of spread of infections across provincial and international borders.


Mask wearing and social distancing


Non-pharmaceutical interventions such as mask-wearing and social distancing, while significantly effective at the local level, were not significantly effective at the national level. The reason is likely related to the differing levels of citizen compliance in communities. Implementation was with the local governments and reflects on political and governance realities. Politicians who implement restrictions without their constituents being consulted and convinced of the necessity of restrictions are likely to lose votes in the next election. In a democracy, citizen engagement with governments remains essential in responding to a crisis such as a pandemic while protecting civil rights according to law. Citizen participation is a central idea in STS in government.


The key role of STS in policy analysis


The UP STS scientists’ work demonstrates that STS approaches to science-informed policy analysis can objectively assess the strengths and weaknesses of government policy. The scientists hope that their study will make policy and governance more effective especially in crises.


Prof. Vallejo is a marine biologist with the UPD-CS Institute of Environmental Science and Meteorology; Dr. Ong, a physician, is a professorial lecturer with the Science and Society Program; and Asst. Prof. Rye is with the Department of Political Science of the College of Social Sciences and Philosophy, UP Diliman. Prof. Vallejo and Dr. Ong also trained under the International Network for Governmental Science Advice (INGSA) in Malaysia on science advice and policy analysis.


Reference:
Vallejo B, Ong RAC , Rye, RS (2023) An Assessment of the Philippines government’s Response to the COVID-19 pandemic based on policy response indices. SciEngg 16 (2) 426-436