UPD-CS Launches Awareness Campaign on Genetic Modification and Gene Editing Research

UPD-CS Launches Awareness Campaign on Genetic Modification and Gene Editing Research

Published: November 14, 2024
By: Eunice Jean C. Patron

#GeneTalks aims to enhance understanding of genetic research while also addressing common misconceptions in the field. (Photo credit: UPD-CS Science Communication Team)

The University of the Philippines – Diliman College of Science (UPD-CS) recently organized a campaign focused on Genetic Modification (GM) and Gene Editing (GE) research in the country, as well as on the challenges faced by its researchers.

 

Titled “#GeneTalks,” the two-part, multi-stakeholder awareness campaign, spearheaded by the UPD-CS Office of the Associate Dean for Research, Innovation, Development, and Enterprise (OADRIDE), aims to foster understanding and elevate the level of public discourse on genetic research by discussing the challenges, opportunities, and potentials of research in GE and GM, while also addressing common misconceptions related to the field. This event series emerged in response to the Court of Appeals’ ruling, case no. CA-G.R. SP No. 00038, which restricts the use, testing, and importation of Genetically Modified Organisms (GMOs), and its potential impact on the academe’s role as a research institution.

 

The first forum held on November 4 and titled “Lab to Field,” explores GM research, its regulatory processes in the Philippines, and its importance in agriculture. The panel of esteemed speakers includes Dr. Ernelea Cao, Professor Emeritus at the UPD-CS Institute of Biology on regulatory processes for GM research and its significance; Atty. Edmund Jason Baranda, Managing Partner of Baranda and Associates, on the Court of Appeal’s ruling on GMOs; and Dr. Lourdes Taylo, Bt Eggplant Project Leader, on Bt eggplant and the role of GMOs in food security and nutrition.

 

“Understanding these dynamics is crucial for ensuring the ethical and responsible conduct of research, and for expanding our insights into GM research for the benefit of scientists, policymakers, and stakeholders,” said  UPD-CS National Institute of Molecular Biology and Biotechnology (UPD-CS NIMBB) Director Dr. Pia Bagamasbad during the forum, who observed that scientists may not be aware of the broader implications of GM research and products.

 

On the other hand, the second forum, held on November 11 and titled “Edit to Innovation,” covers GE technologies, their potential across various fields, and their broader implications. The panel of esteemed speakers includes Dr. Reynante Ordonio, Senior Science Specialist at the Philippine Rice Research Institute, on the current status of biotechnology in the Philippines and GE applications; and Dr. Ron Leonard Dy, Associate Professor at the NIMBB, on the use of GE in molecular diagnostics.

 

“Communicating genetic research through talks such as #GeneTalks provides transparency, allowing the public to ask questions and check the validity of the scientists’ claims. It is a way to bring about societal trust and acceptance.” shared Dr. Ma. Anita Bautista, NIMBB Deputy Director for Research and Extension and Member of the UPD-CS Technical Working Group for GMO-related concerns. “When scientists share information about genetic research and their outcomes, they implicate their authenticity, accountability, and moral and social values.”

 

Participants share their ideas during the mentoring sessions for feedback. (Photo credit: SPS)

For interview requests and other concerns, please contact media@science.upd.edu.ph.

Save Philippine Seas and UP Diliman College of Science Host 2-Day Workshop on Science Communication

Save Philippine Seas and UP Diliman College of Science Host 2-Day Workshop on Science Communication

Published: November 11, 2024
By: Eunice Jean C. Patron

Participants and organizers take a photo in front of the UPD-CS Admin Building. (Photo credit: SPS)

Selected students and researchers from the University of the Philippines – Diliman (UPD) participated in the Commservation Workshop, a two-day event focused on the basics of science communication and conservation. The workshop was organized by the UPD College of Science (UPD-CS) in collaboration with the non-profit organization Save Philippine Seas (SPS) and took place on October 12 and 14.

 

The Commservation Workshop is designed to build the science communication skills of conservation practitioners and enthusiasts, fostering a community of communicators for conservation. The workshop was open to UPD constituents interested in the conservation and restoration of the Philippines’ natural resources and environment, as well as in science communication.

 

A total of 21 participants were selected to join the workshop, and were introduced to the fundamentals of science communication, as well as data visualization, public speaking, grant writing, and fundraising. The activities allowed them to apply what they learned to their conservation efforts.

 

Apart from talks by invited speakers, the Commservation Workshop also included slam book sessions where participants could discuss their conservation efforts and aspirations in detail, as well as interactive mentorship sessions where they presented their communication outputs based on what they learned to the UPD-CS and SPS team for feedback and suggestions.

 

Participants share their ideas during the mentoring sessions for feedback. (Photo credit: SPS)

Participants expressed how the topics discussed during the workshop were beneficial to their initiatives, as well as helped them gain new knowledge and skills. “The Commservation workshop was a real eye-opener for me on the impact of science communication. It emphasized that research is more than just generating knowledge—it’s about making that knowledge accessible and relevant to a wider audience. It reminded me that the best science is the kind that reaches and resonates with people,” shared Kloudene Salazar, one of the participants of the workshop.

 

“As an alumna of UP who took classes under UPD-CS, I know how sessions like these and the networks we build can be transformative for the paths we want to pursue,” said Anna Oposa, Executive Director and Chief Mermaid of SPS. “Science communication is an essential skill for scientists, whether professional or aspiring. By communicating our research outputs and findings to a broader audience like policymakers and communities, we have the potential for greater impact.”

 

The Commservation Workshop invited esteemed speakers to expand participants’ knowledge of science communication. Dr. Inez Ponce De Leon, Associate Professor at the Department of Communication in Ateneo de Manila University, and freelance science communicator Christopher Ng introduced the concept of science communication; Cham Mamador, Data Visualization Specialist at Canva Philippines, discussed data visualization; and Oposa covered public speaking and grant writing.

 

For interview requests and other concerns, please contact media@science.upd.edu.ph.

Documentary on UP Marine Science Institute’s work on Plastics wins at Bantog Awards

Documentary on UP Marine Science Institute’s work on Plastics wins at Bantog Awards

Published: October 15, 2024

By: Eunice Jean C. Patron

MSI researchers are collecting sediment samples from coastal areas, which will be analyzed in their laboratory to detect the presence of microplastic particles. (Photo credit: Microbial Oceanography Laboratory)

A documentary featuring projects of the University of the Philippines – Diliman College of Science’s Marine Science Institute (UPD-CS MSI) received the Best Science and Technology Investigative Story (Audio-Visual) trophy at the Department of Science and Technology’s 2024 Bantog Awards for Science Communication.

 

Produced by the GMA Integrated News Digital Innovation and Strategic Lab for their DigiDokyu segment, the episode, “Ang Plastic Mo! The Philippine Plastic Problem,” delved into the effects of plastic on the country’s marine environment, the livelihoods of fisherfolk, and the food supply.

 

According to the World Bank, as cited in the documentary, the Philippines produces 2.7 million metric tons of plastic annually, 20% of which ends up in the ocean. Published research on plastics frequently mentions the Philippines as a top contributor to marine plastic pollution, yet most of this research is based on model projections and lacks actual baseline data collected from Philippine marine areas. The growing problem of plastics in the country and the lack of accurate data on plastics pushed MSI to create projects addressing plastic pollution.

 

PlastiCount Pilipinas

PlastiCount Pilipinas aims to raise awareness among Filipinos about the widespread presence of plastics, particularly in marine environments and coastal communities, by quantifying plastic pollution in the Philippines, thereby encouraging action to address the issue. The Institute’s innovative project utilizes advanced technologies, such as artificial intelligence (AI), to efficiently count and collect comprehensive and reliable information on plastics in Philippine waters, and to effectively visualize and understand their composition in local communities. Quantifying mismanaged plastics allows the Philippines to establish metrics to track increases or decreases in plastic waste. Identifying plastic debris in the country’s waters can also help in developing policies and solutions tailored to the types of plastic found in specific locations.

 

Circular Explorer Project

In partnership with the cement manufacturing company Holcim and the environmental organization One Earth One Ocean, MSI launched the Circular Explorer Project to empower students and communities to practice environmental sustainability through a science-driven approach to ocean research. The Circular Explorer is the first solar-powered sea vessel designed to collect plastic waste from the water for recycling and is capable of clearing up to four tons of plastic daily with its built-in sensors and plastic collectors.

 

PlasMics Project

MSI also oversees the DOST-funded Plastics in the Marine Environment, Trophic System, and Aquaculture in the Philippines (PlasMics) Project, which aims to determine the prevalence and potential impact of plastics on the marine environment, as well as their implications for biodiversity and aquaculture.

 

Dr. Deo Florence Onda, principal investigator of the Microbial Oceanography Laboratory (MOLab) responsible for these projects, shared that MSI is now working with agencies such as the Department of Environment and Natural Resources to harmonize the projects’ methodologies for national baselining. “The technology we are developing is already being adopted by national government agencies. That’s what we want – the university develops technology, and the national government adopts it for roll-out, application, and institutionalization.” MOLab also aims to make its initiatives more accessible to the general public through collaborations with media organizations.

 

DOST’s Bantog Awards for Science Communication aims to expand public interest in science, technology, and innovation, as well as to enhance science literacy in the Philippines. This year’s theme is “Driving Developments through Science Communication.”

 

For interview requests and other concerns, please contact media@science.upd.edu.ph.

UP Mathematicians Introduce a Different Approach in Detecting Potential Stock Market Crashes

UP Mathematicians Introduce a Different Approach in Detecting Potential Stock Market Crashes

Published: October 8, 2024

By: Harvey L. Sapigao

The process of Topological Data Analysis. (Photo credit: Riñon et. al. 2024)

A data analysis method that borrows concepts from topology – the so-called “rubber-sheet geometry” – may soon find its way to a stock trader’s toolkit in analyzing market movements. This method, called Topological Data Analysis (TDA), uncovers patterns in large datasets, preparing them for deeper analysis.

 

In a study published in the Philippine Journal of Science, Ela Mae Riñon and Dr. Rachelle Sambayan of the UP Diliman College of Science Institute of Mathematics (UPD-CS IM) demonstrated that TDA can be used as an early warning signal for stock market crashes. Their study, which analyzed stock data of three Philippine companies from 2019 to 2021, successfully anticipated periods when the market was about to crash.

 

“The findings suggest that [TDA] can help identify industries most affected during economic downturns, such as the COVID-19 pandemic, aiding investors and policymakers in minimizing risks,” they said.

 

The T in Topological Data Analysis

 

To understand TDA, it may be helpful to compare it with how we observe stars. At first glance, the night sky appears as a seemingly random plot of stars scattered across the vast canvas of the universe. However, with extended observation, patterns emerge: clusters of stars, constellations, and voids become apparent the moment we recognize them. As we continue to gaze at the sky, the random stars fade into the background, while the clusters, constellations, and voids take the spotlight.

 

This effect is similar to what TDA does with large sets of data points. Essentially, TDA reveals hidden geometric structures within datasets, allowing insights to be drawn from what previously looked like an ambiguous clump of points. “TDA helps uncover patterns, such as clusters forming constellations, loops, or voids,” said the authors.

 

One tool in TDA, called persistent homology, follows a series of steps to systematically uncover patterns. First, researchers draw a small ball around the data points. Next, they gradually expand the balls until some of them overlap. When this happens, they connect the corresponding points. The balls continue to expand until the points form various figures, which are then classified into what are called homology groups.

 

Researchers classify the figures into three homology groups: connected components, which are open shapes like line segments; loops, which are closed shapes like triangles; and cavities, which are shapes that extend to the third dimension. As the balls expand, the figures can change from one homology group to another. A connected component, for example, might attach to a data point that closes it off, transforming it into a loop.

As the balls expand, the points connect, forming different homology groups. (Photo credit: Riñon et. al. 2024)

Throughout this process, researchers observe how quickly the figures change homology groups. Figures that switch groups over a short range of ball sizes are considered noise, while those that persist for wider ranges are deemed more significant. Eventually, when the balls are large enough, they will all overlap and all points will be connected into one big structure, marking the end of the process.

 

Which figures quickly change and which persist is the core idea of TDA, revealing key features of the data. Moreover, the authors explained that “unlike standard methods, TDA is robust to noise and can detect complex patterns that might otherwise go unnoticed, offering a deeper understanding of high-dimensional data.”

 

Putting TDA to the Test

 

Dr. Sambayan and Riñon applied TDA to the stock price data of three Philippine companies – Cebu Air (CEB), PAL Holdings (PAL), and Century Pacific Food (CNPF) – from January 2019 to January 2021. They found that when the market was about to crash, the data points began to cluster together, which made their corresponding figures more likely to change homology groups. In other words, the persistence of homology groups weakens as the stock prices start to plummet.

 

“This weakening of persistence is unexpected because it reveals a distinct change in the data’s topological structure during market downturns, which contrasts with the scattered point clouds observed during stable periods,” the authors explained.

 

To track these changes, they used a persistence landscape, a chart that maps out the crash probability of a stock. In 2019, during a period when CEB was about to crash, its persistence landscape spiked, indicating a high crash probability of 40-60%. Similarly, in early 2020, the landscape showed a high crash probability prior to another CEB crash, which was attributed to pandemic travel bans and lockdowns.

 

Their study also revealed that TDA is indeed robust to noise, which refers to ordinary fluctuations within the data. Stock prices naturally fluctuate, but not every dip signals an impending crash. Unlike CEB, both PAL and CNPF were more stable during the onset of the pandemic. Although they experienced minor dips during this period, they did not experience a significant crash, which the model correctly anticipated.

 

However, the authors noted that they only applied the analysis to three companies over a brief period and that other markets or time frames might yield different results. “Additionally, the study’s approach to determining thresholds and window sizes may need further refinement to ensure consistency and accuracy in different contexts,” they said.

 

To further test TDA, the authors recommend extending the analysis to other markets and time frames. “Another avenue for future research is applying the TDA approach to other types of time series data, such as exchange rates, to explore its effectiveness in detecting structural changes and understanding the behavior of stock prices and other financial indicators under different economic conditions,” they concluded.

 

For interview requests and other concerns, please contact media@science.upd.edu.ph.

 

References:

Riñon E.M, and Sambayan R. (June 2024). Topological Approach for Detection of Structural Breakpoints in Philippine Stock Price Data Surrounding the COVID-19 Pandemic. Philippine Journal of Science, 153(3): 1177–1188. https://philjournalsci.dost.gov.ph/129-vol-153-no-3-june-2024/2118-topological-approach-for-detection-of-structural-breakpoints-in-philippine-stock-price-data-surrounding-the-covid-19-pandemic

 

UP Scientists Create Thermoresponsive Polymers for Potential Biomedical Use

UP Scientists Create Thermoresponsive Polymers for Potential Biomedical Use

Published: October 4, 2024

By: Eunice Jean C. Patron

Thermoresponsive polymers are molecules that undergo significant changes in their properties in response to temperature changes and are widely used in biomedicine, such as drug delivery, tissue growth, and gene transfer, as noted by researchers Ward and Georgiou in their 2011 study.

 

One example of a thermoresponsive polymer is poly(N-isopropylacrylamide), which is used to deliver drugs, such as calcitonin and insulin, to their target organ. According to scientist Dirk Schmaljohann, poly(N-isopropylacrylamide) keeps the drug intact as it passes through the stomach, and once it reaches the intestines, which have a different pH level, the polymer breaks down and releases the drug.

 

While there are already existing conventional methods to synthesize polymers, it is difficult to control how monomers—small molecules that make up polymers—connect. This leads to varying polymer chain lengths, which affect the performance of the polymers. This prompted chemists from the University of the Philippines – Diliman College of Science (UPD-CS) to identify a simple, inexpensive, and environmentally friendly approach of creating thermoresponsive polymers.

Synthesis of two different architectures of copolymers of MMA and DEGMEMA using RAFT polymerization in [HPY][PF6].

(Photo credit: Madrid et al., 2024)

Using the Reversible Addition Fragmentation Chain Transfer (RAFT) polymerization, Ludhovik Luiz Madrid and Dr. Susan Arco from the UPD-CS Institute of Chemistry (UPD-CS IC), along with Ser John Lynon Perez of the UPD-CS Natural Sciences Research Institute (UPD-CS NSRI), successfully created thermoresponsive polymers using two monomers—di(ethylene glycol) methyl ether methacrylate (DEGMEMA) and methyl methacrylate (MMA)—in  a hexylpyridinium ionic liquid, N-hexylpyridinium hexafluorophosphate ([HPY][PF6]). Both linear and hyperbranched structures were successfully synthesized, using ethylene glycol dimethacrylate (EGDMA) as the crosslinking agent for the hyperbranched copolymer. The polymers produced by the researchers were biocompatible, meaning they can interact with living body tissues without causing adverse reactions.

 

“RAFT polymerization helps control the growth of polymer chains by mitigating the formation of chains that can no longer grow (a.k.a. ‘dead’ polymers), thereby creating a narrower molecular weight distribution  which can allow more tailored polymer designs or properties,” Madrid explained. Solvents used in RAFT polymerization are also typically organic and volatile, posing environmental and health risks. To lessen these risks, the researchers used [HPY][PF6], a type of ionic liquid that has better polymerization kinetics and is less harmful to the environment.

 

Apart from demonstrating the effectiveness of synthesizing polymers with [HPY][PF6] through RAFT polymerization, the study introduced new possibilities in polymer research. “The results open up the potential for using other hexylpyridinium ionic liquids to create dual-responsive polymers (e.g. responsive to both temperature and pH), which are valuable for biomedical applications such as drug delivery,” Madrid concluded.

 

For interview requests and other concerns, please contact media@science.upd.edu.ph.

 

References:

 

Madrid, L. L., Perez, S. J., & Arco, S. (2024). RAFT copolymerization of methyl methacrylate and di(ethylene glycol) methyl Ether methacrylate in a hexylpyridinium Ionic liquid. Journal of the Chinese Chemical Society. https://doi.org/10.1002/jccs.202400197

 

Schmaljohann, D. (2006). Thermo- and pH-responsive polymers in drug delivery. Advanced Drug Delivery Reviews, 58(15), 1655-1670. https://doi.org/10.1016/j.addr.2006.09.020

 

Ward, M. A., & Georgiou, T. K. (2011). Thermoresponsive polymers for biomedical applications. Polymers, 3(3), 1215-1242. https://doi.org/10.3390/polym3031215

Scientists Confirm Two Domesticated Buffalo Species in PH

Scientists Confirm Two Domesticated Buffalo Species in PH

Published: September 17, 2024

By: Eunice Jean C. Patron

Domesticated buffaloes (Bubalus bubalis) in the country have traditionally been classified into two subspecies: swamp buffaloes and riverine buffaloes. A recent study, however, provides evidence that these two are not subspecies, but are instead distinct from each other.

A Philippine native carabao (Bubalus kerabau Fitzinger, 1860) dam and her calf grazing in Pitogo Island, Bohol.

(Photo credit: Lilian P. Villamor, from Ruane et al., 2023)

Swamp buffaloes (Bubalus bubalis carabanensis) are primarily used to assist farmers with tilling the land, transporting tools, and, alternatively, for meat, milk, hide, and manure, which is used as organic fertilizer. Riverine buffaloes (Bubalus bubalis bubalis), on the other hand, are mainly used in milk production. In the Philippines, crossbreeding and backcrossing these two breeds on a large scale helps create animals with improved potential for milk and meat production, despite their differences. Hybridization of swamp and river buffaloes has limited success, sometimes producing viable offspring that don’t achieve the desired traits.

 

A team of researchers conducted an investigation to clarify the taxonomic designation of swamp and riverine buffaloes in the Philippines. They discovered that the DNA sequences of the genes from both swamp and riverine buffaloes are distinguishable and that their chromosome numbers are different, affirming that they are two distinct species, not just subspecies of Bubalus bubalis.

 

The research team is comprised of Dr. Ian Kendrich C. Fontanilla, Nelvie Fatima Jane A. Soliven, John Gregor A. Roño, Francis L. Fontanilla, Emerson R. Servo, and Dr. Ernelea P. Cao of the University of the Philippines – Diliman College of Science’s Institute of Biology (UPD-CS IB) and Dr. Lilian P. Villamor, Therese Patricka C. Cailipan, Alexander M. Paraguas, and Aivhie Jhoy E. Cuanang from the Department of Agriculture – Philippine Carabao Center (DA-PCC).

 

“These results corroborate the observed differences in their appearances. Swamp buffaloes can be identified by the white or light gray markings on their lower jaw and brisket, known as a chevron, as well as their lighter skin and coat color compared to riverine buffaloes. They are also smaller, weighing between 325 and 450 kg, and have crescent-shaped horns. They are mainly used as draught animals,” said Dr. Villamor, citing data from her previous studies on buffaloes. “River buffaloes, on the other hand, are larger, weighing between 450 and 1,000 kg, and have curly horns. They are primarily raised for milk and meat production.”

A riverine buffalo (Bubalus bubalis Linnaeus, 1758). (Photo credit: Therese Patricka C. Cailipan and Sonny C. Ramos)

According to the team, the Philippine native carabao, which is currently classified as Bubalus bubalis carabanensis, should be now considered as Bubalus kerabau Fitzinger, 1860. “The reclassification of the Bubalus bubalis carabanensis to Bubalus kerabau Fitzinger, 1860 supports earlier assumptions that riverine and swamp buffaloes are distinct,” added Dr. Fontanilla. “Confusions on the classifications of the two buffaloes have implications on the breeding program of these species.”

 

As their study was limited to examining the chromosomes of only swamp and riverine buffaloes, the researchers plan to include chromosomes from crossbred buffaloes in future studies to gain new insights into how these different types of buffaloes are genetically related and potentially improve the classification of the Bubalus bubalis.

 

The study, titled “Molecular Data and Karyotype Revealed Two Distinct Species of Domesticated Water Buffaloes in the Philippines,” offers valuable insights into the diversity of domesticated buffaloes, and can guide conservation and management efforts, particularly in developing potential hybrids with desired traits. It was published in the Philippine Journal of Science, an open-access, single-blind peer-reviewed journal on natural sciences, engineering, mathematics, and social sciences.

 

For interview requests and other concerns, please contact media@science.upd.edu.ph.

 

References:

 

Cailipan, T. P., Paraguas, A., Cuanang, A. J., Soliven, N. F., Roño, J. G., Fontanilla, F., Servo, E., Cao, E., Fontanilla, I. K., & Villamor, L. (2023). Molecular data and karyotype revealed two distinct species of domesticated water buffaloes in the Philippines. Philippine Journal of Science, 152(5). https://doi.org/10.56899/152.05.27

 

Cailipan, T.P.C., Villamor, L.P. 2021.  Molecular characterization of SRY gene in the Philippine Carabao (Bubalus bubalis) swamp buffalo populations. SciEnggJ 14(2):291-296.

 

Ruane, J., Mba, C., Boettcher, P., Koskela, J., Mair, G., & Ramasamy, S. (2023). Case studies of the use of agricultural biotechnologies to meet the needs of smallholders in developing countries. Food & Agriculture Org.

 

Villamor, L.P., Takahashi, Y., Nomura, K. and Amano T. 2021. Genetic diversity of Philippine Carabao (Bubalus bubalis) using mitochondrial DNA D-loop variation: implications to conservation and management. Philippine Journal of Science, 150(3): 837-846.

Here’s How UP Physicists are Helping with the Hunt for Gravitational Waves

Here’s How UP Physicists are Helping with the Hunt for Gravitational Waves

Published: September 13, 2024

By: Harvey L. Sapigao

A black hole inside an accretion disk. (Photo credit: BoliviaInteligente on Unsplash)

In 1916, Albert Einstein theorized that two merging black holes create ripples in the spacetime fabric, similar to how a pebble creates ripples in a pond. These ripples, called gravitational waves, stretch and squeeze spacetime in amounts so minuscule that they were once believed to be too faint to detect.

 

But a century later, the Laser Interferometer Gravitational-Wave Observatory (LIGO) in the US, an L-shaped facility with arms spanning four kilometers each, detected minute discrepancies in how long lasers travel through each arm, signaling the first detection of gravitational waves.

 

Now, scientists are preparing to launch a more sophisticated observatory into space, aiming to detect even fainter gravitational waves or those beyond LIGO’s capabilities. This space-based facility, known as the Laser Interferometer Space Antenna or LISA, is a triangular observatory with sides spanning tens of millions of kilometers and is set to launch in the 2030s.

 

As preparation ramps up, scientists around the world are pitching ideas to improve LISA’s detection capabilities. Dr. Reinabelle Reyes and her former graduate student Marco Immanuel Rivera, from the UP Diliman College of Science’s National Institute of Physics (UPD-CS NIP) recently published a study identifying a set of parameters that could improve the analysis of signals coming from LISA and future gravitational-wave observatories.

 

Unlike LIGO, which mainly detects gravitational waves coming from two stellar-mass black holes, LISA hopes to detect a type of gravitational wave coming from compact objects – such as neutron stars, white dwarfs, and stellar-mass black holes – orbiting supermassive black holes. “When a stellar-mass black hole orbiting a supermassive black hole falls into it, an extreme-mass ratio inspiral (EMRI) gravitational-wave signal is produced,” Dr. Reyes and Rivera explained.

 

One complication with detecting EMRIs is that the environment where the compact object-black hole pair resides can considerably affect the EMRIs they emit. For example, supermassive black holes are often surrounded by glowing rings called accretion disks, which can modify the EMRI signal just as the Earth’s atmosphere distorts light from faraway stars.

 

By understanding how these environmental features affect EMRIs, astronomers can not only filter out noise from the signal but also learn about the environment itself. For instance, by studying the imprints of the environment on the gravitational wave signal, astronomers can infer the density of the accretion disk. 

 

Their study considered three environmental factors that may substantially influence the EMRI signal: accretion, gravitational drag, and gravitational pull. Their analysis determined the most measurable parameter combination, which is heavily dominated by these environmental effects. They also estimated how precisely these parameters can be measured—an essential factor for extremely sensitive detectors like LISA.

 

Their analysis is built upon a mathematical tool called the Fisher matrix, which evaluates how accurately an experiment can measure different observables. To illustrate, imagine a catch basin designed to collect water, rocks, and leaves. The Fisher matrix determines and quantifies how effectively the basin can catch each object separately, even before the experiment is set out.

 

“The Fisher matrix is used by astrophysicists to estimate the expected precision to which certain properties can be measured from a given signal to be observed in a future detector,” explained the authors.

 

While their study shows promise, Dr. Reyes and Rivera noted that modeling EMRIs is challenging due to strong gravity effects, and more accurate modeling is needed.  “It will be interesting to compare with calculations based on the newer waveform models which are adapted for EMRIs, as well as those which contain the effects of non-trivial environments,” the authors said.

 

“In the future, we hope to see how the parameter combinations we presented in this study can be applied directly in improving parameter estimation methods used in gravitational-wave astronomy, such as stochastic samplers,” the authors concluded.

 

For interview requests and other concerns, please contact media@science.upd.edu.ph.

 

Rivera, M.I. and Reyes, R.C. (2024) Measurable parameter combinations of environmentally-dephased EMRI gravitational-wave signals, New Astronomy, 112, p. 102263. https://doi.org/10.1016/j.newast.2024.102263

UP Researchers Investigate E. coli Levels in Urban Farm Vegetables

UP Researchers Investigate E. coli Levels in Urban Farm Vegetables

Published: August 27, 2024

By: Eunice Jean C. Patron

A type of bacterium called Escherichia coli (E. coli), found in the feces of humans and animals, is often released into bodies of water such as streams. Although most E. coli strains are harmless, some can cause foodborne diseases such as gastroenteritis, typhoid fever, and dysentery. Feces are a major source of microbial contamination in fresh produce. With the rise of urban farming in the Philippines during the COVID-19 pandemic, it is essential to monitor fresh produce from urban farms to recognize and address food safety issues immediately.


Scientists from the University of the Philippines – Diliman College of Science (UPD-CS), supported by the Department of Agriculture – Bureau of Agricultural Research (DA-BAR), assessed vegetables from wet markets and urban farms in Metro Manila during the peak of the pandemic to detect and quantify the presence of E. coli.

Researchers gather samples of mustasa, or mustard greens (Brassica juncea), at New Greenland Farm in Bagong Silangan, Quezon City. (Photo credit: The Research Team)

Dr. Pierangeli Vital, Donnabel Sena, Czarina Jay Catapat, and Ma. Christine Jasmine Sabio from the UPD-CS Natural Sciences Research Institute (UPD-CS NSRI), along with Dr. Windell Rivera of the UPD-CS Institute of Biology (UPD-CS IB) gathered 419 vegetable samples from three urban farms and four major wet markets in Metro Manila. The group detected E. coli in 13.60% of all the samples. The presence of E.coli in the samples from urban farms was also higher than in the samples obtained from wet markets.

 

According to Dr. Vital, high levels of E. coli in the samples from urban farms could be linked to various factors, such as lack of thorough post-harvest processing, unlike the samples from wet markets. “As observed in the urban farm sampling sites, they frequently use rainwater, pond water, and well water for irrigation, mainly for economic reasons, but this increases the risk of bacterial contamination,” she said.

 

Animals such as dogs, cats, and chickens often roam around urban farms, which raises the risk of microbial contamination in the irrigation water and soil where the vegetables grow. The researchers considered these as areas for improvement in developing urban farming practices.

 

“This research, together with our past research on agricultural food safety, is and was used in creating and adopting Philippine National Standards (PNS) on pre- and post-harvest microbial food safety in agriculture, with initiatives spearheaded by the DA – Bureau of Agriculture and Fisheries Standards (DA-BAFS),” shared Dr. Vital.

 

The researchers stated in their paper that the results could provide a factual basis for regulating, controlling, and eliminating food pathogen contamination in fresh produce, thereby helping policymakers implement regulations that ensure food safety. Even so, Dr. Vital mentioned that preventing foodborne illnesses such as E. coli can also be done by Filipinos in their own homes.

 

“Proper handling and cooking must be practiced at home, which involves simple steps such as thoroughly washing hands and kitchenware as well as disinfecting table surfaces when preparing food, using clean water when washing vegetables, effectively separating cooked and raw foods, and storing food the right way,” Dr. Vital added. “Following these simple steps can significantly help reduce the risks of foodborne illness at home and in the community.”

 

They plan to include more surveillance of relevant foodborne pathogens and conduct the study on a national level, in addition to investigating the antimicrobial resistance of the bacteria. These endeavors will provide significant data for analyzing trends in microbial food safety in the Philippines.

 

The paper, titled “Thermotolerant Escherichia coli contamination in vegetables from selected urban farms and wet markets in metro Manila, Philippines at the height of COVID-19 pandemic,” was published in the Asia-Pacific Journal of Science and Technology, a peer-reviewed journal covering research fields such as engineering, agricultural sciences, technology, and health sciences.

 

For interview requests and other concerns, please contact media@science.upd.edu.ph.

 

References:


Vital, P., Rivera, W., Sena, D., Catapat, C. J., & Sabio, M. C. J. (2024). Thermotolerant Escherichia coli contamination in vegetables from selected urban farms and wet markets in Metro Manila, Philippines at the height of COVID-19 pandemic. Asia-Pacific Journal of Science and Technology, 29(03), APST–29. https://doi.org/10.14456/apst.2024.44

Response of behalf of the MS/PhD Graduates

Response on behalf of the MS/PhD Graduates

To our guest speaker, National Artist Kidlat Tahimik, to our Chancellor, Chancellor Vistan, to our dean, Dr. Giovanni Tapang, academicians, university officials, institute directors, faculty, parents, guests and of course graduates, magandang gabi po sa ating lahat.


The theme for today’s commencement is “Science in the Service of Society.” Since I’m not particularly experienced in writing speeches, I’ll approach this topic the way we tackle complex scientific journals—by defining and discussing each term.


Let’s start with the word “science.” After spending at least four years immersed in this field, I believe its meaning is already familiar to us. However, I’d like to share a glimpse of the state of science in our country based on my experiences.


My adviser, Dr. Nathaniel Hermosa came back to the Philippines from his postdoctoral position as a Balik-Scientist fellow to establish his own laboratory in 2015. I was fortunate to be one of his first advisees. I witnessed firsthand the process of building a laboratory from the ground up, including the relatively tedious process of procuring equipment. I have seen how researchers, including my mentors, often have to justify their work as addressing pressing issues like poverty just to secure financial support in their projects. I, myself have experienced being disheartened with these circumstances. Last 2023, our work was selected as a finalist for the Best Student Research Award in Spain. Despite the university’s generous support, I was unable to attend the conference in person due to inadequate funding.


Let me be clear: our university is incredibly supportive and generous with research funding, but these challenges are part of the reality we face. Minsan nakaka-frustrate, madalas nakaka-lungkot. Yet, despite these obstacles, we continue to excel, producing great research papers and nurturing world-class scientists.


During one research meeting, I asked my adviser, “Why did you choose to return and conduct experiments here in the Philippines when it might be easier to do so abroad?” His response, in essence, was that while we might lack in resources and funding, we make up with ingenuity and resourcefulness. This may be an adaptive skill, but our lack forces us to think outside the box and come up with creative solutions to problems.


Next word is service. For this part, let me tell you a story.


Tungkol ito sa isang mag-asawang magsasaka na nagngangalang Ceasar at Aurora. Sila ay may tatlong anak: isang panganay na babae at dalawang lalaki. Upang mapagtapos ang kanilang mga anak, kinailangan nilang maghanap ng iba pang trabaho bukod sa pagsasaka. Nagsimulang mag-buy and sell si Ceasar ng mga baboy, at naging manininda naman sa palengke si Aurora. Ang kanilang panganay na anak na si Mona ang katulong ng kanyang ina sa pagtitinda sa palengke.


Sa murang edad, namulat si Mona sa hirap ng buhay at sa sakripisyo ng kanyang mga magulang upang mapag-aral silang magkakapatid. Sa buong apat na taon ng high school, mayroon lamang siyang isang pares ng uniporme at isang pares ng sapatos na pinilit niyang pinagkakasya sa kanyang lumalaking paa. Nakapagtapos ng high school si Mona, ngunit dahil sa hirap ng buhay, sinabihan siya ng kanyang ina na baka hindi na nya ito kayang suportahan sa pag-aaral nito sa kolehiyo. Pursigidong makatapos ng pag-aaral si Mona, kaya naghanap siya ng paraan upang tulungan ang kanyang sariling makapag tapos. Nag-simula syang magbenta sa kanyang mga classmates ng kanyang mga paninda. Nag tiis syang mag-meryenda sa isang pirasong muncher o tattoos habang pinapanood ang kanyang mga kaklaseng kumain ng softdrinks at piattos. Sa awa ng Diyos, nakakuha sya ng scholarship at tuluyang nakapagtapos ng kolehiyo.


This story is not mine but that of my mother’s and grandparents’. My mother was the first in her clan to earn a college degree. I am the first in our immediate family to graduate in UP.


We should remember that these diplomas and degrees are not solely the result of our individual efforts. We are here because of the collective support and sacrifices of those who stood by us throughout this journey. We are reaping the fruits of their labor and dedication.


Where does service fit into all this? Service and sacrifice go hand-in-hand. True service is never comfortable; it involves sacrificing something of our own and going out of our way to help others.


My grandfather Ceasar, who passed away during the 2020 pandemic, is not here to witness this moment. While we may never fully repay the debt we owe to those who came before us, we can certainly pay it forward. We can become mentors to the next generation of scientists. We can serve our community with our knowledge and skills. We can conduct research that advances science for the betterment of society.


Finally, let’s reflect on the word “society.”


I had a hard time concentrating on writing this speech due to the recent flood that has affected so many this week. In the middle of the typhoon last Wednesday, my husband had to rescue our pamangkins in Cainta because the flood is already approaching their second floor. It is really challenging to celebrate today however, I believe this is precisely the moment to reflect on the true meaning of this ceremony.


I took some time to research the meaning behind our UP Sablay. According to OUR’s website, the word “Sablay” refers to an indigenous loose garment that, though simple, is traditionally worn for formal occasions. As a verb (isablay), it means to drape a precious object, such as this garment, over one’s shoulder, symbolizing value and respect for that object.


Today, we are giving value and honoring not only our efforts but also the people who have paved the way for us—our seniors, mentors, and the entire community who helped us wear this Sablay with pride. We are showing respect for the dedication and service of everyone who made our journey possible.


Our UP Sablay represents more than personal achievement; it symbolizes our responsibility to contribute to society. As we wear our Sablays today, let us remember that our journey is a testament to the collective effort and dedication of our community. It’s a call to use our knowledge, skills, and achievements to serve others, to uplift those around us, and to address the pressing needs of our society.


As my call to action, I want to repeat what I said in our institute’s recognition this morning.

Pagsilbihan ang kapwa, pagsilbihan ang sambayanan. Gamitin natin ang pananaliksik bilang instrumento ng pagbabago.


Let’s use our education in paying it forward and may our legacy be one of bettering the next generation.


Thank you, and congratulations to the College of Science Class of 2024. Mabuhay ang mga siyentista ng bayan.

Response of behalf of the BS Graduates

Response on behalf of the BS Graduates

Maganda’t mabuting araw sa inyong lahat! Ako si Sean Brendan, mula sa Pambansang Linangan ng Pisika.


Tuwing iniisip ko kung bakit ba ‘ko nandito sa pisika’t agham, palagi akong walang depinitibong sagot. No’ng bata ako pinangarap ko maging astronot. ‘Di ko alam. Baka dahil ang astig ng kanilang damit, tapos sasakay sa ispeyship. Ang lupit din tingnan ng mga kemistri-kemistri. Pati ‘yang mga daynosor na ‘yan. Palaging paiba-iba ang gusto ko.

Bilang mga siyentista ng hinaharap, na minsa’y sinilaw rin ng mga bitwin, numero, palaka, o kung anumang dahilan kung bakit tinahak ang daang siyensya, kahit sa’n pa man tayo dalhin ng ating pagtuklas, alam nating madaling malunod sa angking ganda nito—sa sarap ng pakiramdam tuwing nakaka-solb tayo ng ekweysyon, sa pagpaypet ng kemikal, sa pagdila ng bato, o maging sa pakiramdam na, …, basta, “ang kul pakinggan”. Pero minsan, malungkot. Totoo ang mga nararamdaman nating kalungkutan sa “‘di tayo napili”, “‘di tayo nanalo”, “‘di tayo nakapasa kasi mababa ang gan’to”. “Kapag ba nagpatuloy ako sa
siyensya, magiging matagumpay pa ba ‘ko kung ngayon palang, ‘di na ‘ko magaling?”

Kadalasang ikinakabit ng mga pamantayang internasyual ang tagumpay sa agham sa ating h-index, o kung anumang iskolarling batayan sa bilang ng ating mga nailathala, kung ilang beses ito isinipi, at iba pa. Ang iba nama’y ikinakabit ang tagumpay sa kung ga’no kataas ang ating makakamit, sa rekognisyon at kasikatan na makukuha natin sa akademikong komunidad mula sa pagtuklas ng mga bagong resulta o pagbuo ng mga abstraktong teorya. Ang iba pa’y ikinakabit ang tagumpay sa kung ga’no kalayo ang ating mararating, kung ga’no kalaki’t maimpluwensiya ang mga prestihiyosong institusyong akademiko o industriyal ang ating mapupuntahan. Maraming pagsasalarawan sa iba’t ibang puntong pibotal na sumusukat sa kung ga’no tayo katagumpay sa ating mga larangan. Kung ngayon sa mga linangan, mga grado, sa akademya’t industriya, marami pang metrikong ginagamit para sukatin tayo. Bagamat nagagamit ito sa pagsukat ng kasanayan, pananagutan, pagpuna, pagdedesisyon, at pagpapabuti, ang mga ito rin ay nagiging kawnterproduktib.

Sa ganitong kapaligiran, ang presyur na umayon ay maaaring nakapaghihina sa pagkamalikhain. Ang mismong diwa ng siyentipikong pagdiskubre—ang pagsasaliksik at paghahamon sa istatus kwo—ay napahihina ng walang tigil na paghahabol sa mga paborableng sukatan. Gayunpaman, maging sa harap nitong mga mahihirap at ‘di magagandang realidad sa mundo ng agham na nagdudulot ng malawakang kumpetisyon sa trabaho at paghina ng produktibong gawa—sa mukha ng krisis sa edukasyon, limitadong akses sa impormasyon, kakulangan sa pondo, at sa kadiliman ng klimang pulitikal—hindi pa rin dapat na kalimutan ang mga mamamayan.


Habang nauunawaan natin na ang mga pananaliksik ay may kanya-kanyang kalakasan, sakop, at limitasyon—may direktang impak man sa mga komunidad at napapanahong isyu, o wala dahil ito’y abstrak at wala pa masyadong nakaiintindi—nais kong ipaalala sa lahat na ang ating pananaliksik, ang kabuuan ng ating trabaho, ay hindi umiiral isang bakyum. Ito’y isang intigral na bahagi ng mas malawak pang ekosistemang kinabibilangan din ng mga taong sumusuporta sa ating pananaliksik at ng publiko na ang buhay ay nais nating pagbutihin no’ng una pa lamang. Kaya kahit ano pa man ang sabihin ng mga
sukatan tungkol sa kakayahan at tagumpay natin, h’wag nating hayaan na magtabon ito sa tunay na pagkamalikhain, sa tunay na paghahangad ng kaalaman, at syempre sa integridad ng agham, dahil ang bayan ay nakasandal sa atin.


At habang naiintindihan din naman natin na ‘di makapagbubuhos ang walang laman na bukal—na tayo ri’y napapagod, nauubos, nalulubog sa kahirapa’t, nawawala ang pangarap para sa mamamayan dahil sa minsang pangangailangang unahin ang sarili—nais ko ring ipaalala na ang ating pagpupunyagi ay magkakaroon pa rin ng mas malalim na kahulugan. Kapag sumikat na muli sa wakas ang araw sa napakatagal at napakadilim nating gabi, makababalik din tayo sa pagpapanday ng landas para sa mga susunod na henerasyon.
At ‘di rin dapat natatapos ang siyensya sa papel at pagsasaayos ng mga metriko. ‘Di rin sa pagbuo ng mga aplikasyon nito.


H’wag tayong magtapos sa pagtutok lamang sa ating mga pag-uusap sa isa’t isa rito, sa pagbabahagi sa mga kapwa lamang na siyentista sa mga kumperensya’t kumbensyon, kundi iparating din natin ang ating mga natutuklasan sa mga lente ng mga nararanasang realidad na nakaaantig sa mga tao. Hindi sapat na alam lamang natin na ang ating ginagawa ay para sa tao, para sa bayan, naiuugnay din dapat natin ito sa adbokasiya’t aktibismo. Dapat naisasalin din natin ang mga kumpleksiting ito sa mga malilinaw at makabuluhang naratibong akesibol para sa mga bata, sa mga matatanda, sa mga taong nasa ibang larangan, sa mga taong may limitadong kakayahan, maging sa mga taong kinaaayawan—para sa lahat—dahil ang ating agham ay ang ating pagmamahal, at ang ating pagmamahal ay mapagbuklod at mapagpalaya.


Iparinig at iparamdam natin ang ating agham.